Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.

It’s Senior year at East Great Falls. Annie, Kayla, Michelle, and Stephanie decide to harness their girl power and band together to get what they want their last year of high school.

The characters we met a little more than a decade ago are returning to East Great Falls for their high-school reunion. In one long-overdue weekend, they will discover what has changed, who hasn’t and that time and distance can’t break the bonds of friendship. It was summer 1999 when four small-town Michigan boys began a quest to lose their virginity. In the years that have passed, Jim and Michelle married while Kevin and Vicky said goodbye. Oz and Heather grew apart, but Finch still longs for Stifler’s mom. Now these lifelong friends have come home as adults to reminisce about – and get inspired by – the hormonal teens who launched a comedy legend.